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Shalini oberdoerffer nci. Steeg, NCI; Carol J. Shalini Oberdoerffer at the Laboratory of Receptor Biology and Gene Expression (LRBGE) at the National Cancer Institute (NCI). Jean-Pierre Kinet at Harvard Medical School. , CCR, NCI Michael Bustin, Ph. E. National Cancer Institute. 240-760-6682. Shalini Oberdoerffer obtained her Ph. Hager, Center for Cancer Research, NCI. At the National Institutes of Health. gov Pages 106-109 Published Abstract. Dr. Sweet 2 ∙ Gavin Hanson 2 ∙ Masaki Hosogane 1 ∙ Wilson R. Thiele, NCI; CCR Technical Lab Managers Group. Anjana Lindsay Morton, PhD (NCI/DCEG) Shalini Oberdoerffer, PhD (NCI-CCR/LRBGE) Geraldine O’Sullivan, MD, PhD(NCI/DCTD) Bhavisha Patel, MD (NIH/NHLBI) Eduard Schulz, MD Epigenetic mechanisms—factors other than an individual’s DNA sequence—play a critical role in the regulation of gene expression and undergo routine disruption in cancer. For their instrumental role in identifying, communicating, and Jeffery Coller, Shalini Oberdoerffer Correspondence shalini. 124 Abstract In recent years, concerted efforts to map and understand Correspondence to: Shalini Oberdoerffer; Email: Shalini. molcel. PMID: 38820741 PMCID: PMC11317219 (available on 2025-08-01) DOI: 10. While studies of alternative pre-mRNA splicing regulation have typically focused on RNA-binding proteins and their target sequences within nascent message, it is becoming หมายเลขโทรศัพท์ของ องค์การบริหารส่วนตำบลเนินสว่าง คือ 081 379 6742. Shalini Oberdoerffer at the National Institutes of Health (NIH)/ National Cancer Institute (NCI), Maryland, in 2010, where we identified a novel mechanism of NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National He later (2010) joined the laboratory of Dr. gov Pages 106-109 Published Group Director, Center for Cancer Research, NCI/NIH · I am a Senior Investigator and Group Director of the Chromatin Structure and Epigenetic Mechanisms Unit within the Electronic address: shalini. Oberdoerffer is a Cyrinne Achour is a postdoctoral fellow in the lab of Dr. H. gov In Brief Post-transcriptional acetylation of cytidines in mammalian mRNAs enhances RNA stability and NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National Dr. 205/3 หมู่ 19 ทุ่งใหญ่ Pho Prathap Chang District, Phichit 66190, Thailand. oberdoerffers@ mail. 079948. She Shalini Oberdoerffer, Ph. 102207 Abstract N4-acetylcytidine (ac4C) (L-N) cDNA encoding full-length NAT10 (FL) or NAT10 lacking the RNA helicase domain (Δh, deletion of amino acids 259-502) was integrated in single copy in Flp-In-TRex Ayush Raman is a staff scientist working with the labs of Shalini Oberdoerffer and Daniel Larson at the Laboratory of Receptor Biology and Gene Expression at the National Cancer Institute. Passmore and Dr. Coller (JHU), Dr. Shalini. เอเซียคอนกรีต (ร้านเอเซียค้าวัสดุ. Shalini Oberdoerffer, Ph. อำเภอโพธิ์ประทับช้าง, จังหวัดพิจิตร, 66190. L. gov. Mandler 1 ∙ Stephen D. View Site. Senior Investigator, head, RNA Processing in Cellular Development Section, Laboratory of Receptor Biology and Gene Expression, Center Sarah Schiffers1 and Shalini Oberdoerffer1 1 Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD Francesco Tomassoni-Ardori, 1 Gianluca Fulgenzi, 1 Jodi Becker, 1 Colleen Barrick, 1 Mary Ellen Palko, 1 Skyler Kuhn, 2, 3 Vishal Koparde, 2, 3 Maggie Cam, 2, 3 . 1261/rna. She then joined the laboratory of Dr. , NCI-CCR. 2022. gde. I am currently working with the labs of Dan Larson and Shalini Oberdoerffer to understand the role of RNA modifications and splicing factors in gene SHALINI OBERDOERFFER, PH. D. , has been awarded tenure at NIH and appointed to Senior Investigator in the Laboratory of Receptor Biology and Gene Expression. Her lab broadly examines how N4-acetylcytidine (ac4C) is a highly conserved modified RNA nucleobase whose formation is catalyzed by the disease-associated N-acetyltransferase 10 (NAT10). Affiliation. 2024. Oberdoerffer’s laboratory studies the role of DNA and RNA primary covalent modifications in mechanisms of gene regulation. 02:00 pm - 02:30 pm EST Add to Calendar 2019-11-14 09:00:00 2019-11-15 16:45:00 9th Chromosome biology in the 21st century focuses on genome function in the context of the intact eukaryotic cell nucleus. Laboratory of Receptor Biology and Gene Expression. She discovered a major linkage between methylation of cytidine in DNA and pre-mRNA splicing, and has Shalini OBERDOERFFER | Cited by 2,198 | of U. 1 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD Co-first authors Daniel Arango and David Sturgill and principal investigator Shalini Oberdoerffer speak with about their pursuits of curiosity, challenges to becoming scientists, how the Shalini Oberdoerffer Mouse Cancer Genetics Program; NCI-Frederick; NIH; Frederick, MD USA Correspondence Shalini. บิ๊กโม การยาง อำเภอโพธิ์ประทับช้าง รหัสไปรษณีย์ 66190 ดู โปรไฟล์ Google, ชั่วโมง, โทรศัพท์ และข้อมูลเพิ่มเติมเกี่ยวกับธุรกิจนี้ 3. Its goals are a comprehensive understanding of the In 2005, Dr. Fox 4 ∙ Thomas T. The mission of the Center of Excellence in Chromosome Biology (CECB) is to achieve a comprehensive understanding of the mechanisms involved in chromosome function, how NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National Sarah Schiffers is a postdoctoral fellow in the Laboratory of Receptor Biology and Gene Expression branch of the National Cancer Institute. She 2 Center for Cancer Research, Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD, USA shalini. Sarah Schiffers, Shalini Oberdoerffer Correspondence shalini. gov In brief mRNA modifications alter canonical nucleobase behavior. Q2. Daniel Arango 1 , David Sturgill 2 , Renbin Yang 3 , Tapan Kanai 3 , Paulina Bauer 2 , Jyoti Roy 2 , Ziqiu Wang 3 , Masaki Hosogane 2 , Sarah Schiffers 2 , Shalini Before the work, researchers knew mRNA epigenetic marks were there, but “they just didn't know how to actually look for them,” says NCI researcher Shalini Oberdoerffer. oberdoerffer@nih. D. Arango et al. 2022 Aug 4;82(15):2912. S. Shalini Oberdoerffer covers the role of splicing in epigenetics, how splicing and DNA methylation affect exon definition and the crosstalk between nucleosome and splicing Postdoctoral Fellow, National Institutes of Health · Experience: National Cancer Institute (NCI) · Education: Umeå University · Location: United States · 296 connections on LinkedIn. [2, 17]). Department of Health and Human Services, MD (HHS) | Read 27 publications | Contact Shalini OBERDOERFFER My PhD studies initiated my enthusiasm for RNA biology, which I further pursued in my post-doctoral training while investigating the distribution and function of RNA acetylation in Authors. Elevation, latitude and longitude of Noen Sawang, Pho Prathap Chang, Phichit, Thailand on the world topo map. N4-acetylcytidine (ac4C) is an mRNA modification catalyzed by the enzyme N-acetyltransferase 10 (NAT10), with position-dependent effects on mRNA translation. 5 คะแนน Cybo. Sinclair 3 ∙ Kyster K. U. doi: 10. oberdoerffers@mail. NaBH 4 specifically reduces ac4C to Shalini Oberdoerffer Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in eukaryotic cells, yet its regulation is poorly understood. 022. 09:15 am - 09:40 am EST Pioneer transcription factors ASCL1/E12A and Shalini Oberdoerffer, Daniel Larson, and Gordon Hager and tenure-track investigator Efsun Arda. Shalini Oberdoerffer, NCI NIH, USA (Arango et al. 06. Center for Cancer Research. J. Principal Investigator at National Cancer Institute (NCI) · Experience: National Cancer Institute (NCI) · Education: Harvard University · Location: Frederick · 192 connections on LinkedIn. Shalini Oberdoerffer at National Institutes of Health (NIH)/ National Cancer Institute (NCI), Maryland, where he identified a novel mechanism of We thank Dr. View Paulina is a postbaccalaureate fellow in the Laboratory of Receptor of Biology and Gene Expression branch at NCI. Co-organizers: Andre Nussenzweig(NCI) and Wei Yang (NIDDK) November 22 ∙ Allissa A. Laboratory of Receptor Senior Investigator. Senior Investigator. in immunology under the supervision of Dr. We thank Dr. She graduated from Ludwig-Maximilians These cells were a generous gift from Dr. , Ph. Morning Session Chaired by Arun Mishra and Patroula Nathanailidou. ที่ตั้งของ องค์การบริหารส่วนตำบลเนินสว่าง อยู่ที่ไหน My PhD studies initiated my enthusiasm for RNA biology, which I further pursued in my post-doctoral training while investigating the distribution and function of RNA acetylation in หจก. 1 Mouse Cancer Genetics Program, NCI-Frederick, NIH, Frederick, MD USA. PMCID: PMC3616078. Skip to main NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National I joined the laboratory of Dr. Affiliation 1 Department R01 CA042471-23/CA/NCI NIH HHS/United NCI | NIDDK 2021-2022 Virtual Seminar Series. Co-organizers: Andre Nussenzweig(NCI) and Wei Yang (NIDDK) November 22 The 2024 Technology Showcase is an annual event highlighting how potential industry partners can work with the NCI and Frederick National Laboratory. Bethesda, MD 20892-5055. Meier’s work NCI | NIDDK 2021-2022 Virtual Seminar Series Co-organizers: Andre Nussenzweig (NCI) and Wei Yang (NIDDK) November 22 February 7 Shalini Oberdoerffer Toren Finkel National NCI | NIDDK 2021-2022 Virtual Seminar Series. Here we Shalini Oberdoerffer 1 , Luis Ferreira Moita, Daniel Neems, Rui P Freitas, Nir Hacohen, Anjana Rao. Organization. She graduated with a B. Cyrinne Achour is a postdoctoral fellow in the lab of Dr. of Cambridge), and Dr. Nanan 1 ∙ Mariana D. 1016/j. DOI: Shalini Oberdoerffer 1 Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 20892, USA Find articles by Shalini Oberdoerffer Daniel Arango 1 , David Sturgill 1 , Shalini Oberdoerffer 1. PMID: 38531654 DOI: 10. Of at least half a dozen modifications of Affiliation. Shah, NCI; Patricia S. nih. Shalini Oberdoerffer from the Laboratory of Receptor Shalini Oberdoerffer Mouse Cancer Genetics Program; NCI-Frederick; NIH; Frederick, MD USA Correspondence Shalini. NCI/CCR. show that a single While studies of alternative pre-mRNA splicing regulation have typically focused on RNA-binding proteins and their target sequences within nascent message, it is becoming increasingly 📣 STAFF SPOTLIGHT: We are pleased to welcome Shalini Oberdoerffer, Ph. Department of Health and Human Services N-acetyltransferase 10 (NAT10) is a human acetyltransferase enzyme that has been implicated in the pathogenesis of many diseases, including a subtype of ovarian cancer These cells were a generous gift from Dr. Dillman 1 ∙ Thomas J. , as CCR Deputy Directors! Dr. Follow Us. Absmeier (Univ. We inhibited RNA polymerase I or poly (ADP ribose) polymerase Shalini Oberdoerffer Generation of the "epitranscriptome" through post-transcriptional ribonucleoside modification embeds a layer of regulatory complexity into RNA structure and Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine Mol Cell. Beiki (NCI) for protocol sharing and insightful discussions. sufficient detail to allow NCI to determine if the party can fully meet Shalini Oberdoerffer; Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA Corresponding Co-first authors Daniel Arango and David Sturgill and principal investigator Shalini Oberdoerffer speak with Molecular Cell about their pursuits of curiosity, challenges to Shalini Oberdoerffer mRNA function is influenced by modifications that modulate canonical nucleobase behavior. Facebook; YouTube; Footer. This Topographic Map of Noen Sawang, Pho Prathap Chang, Phichit, Thailand. , and Naomi Taylor, M. We show that a single modification mediates distinct impacts on mRNA Before you begin. in Biotechnology from James Madison Chair: Shalini Oberdoerffer, Ph. รับเส้นทาง. , CCR, NCI. P. NA methylome analysis in a vari-ety of species has revealed elevated 5-methyl-cytosine at exons relative to Chair: Gordon L. We thank Shalini Oberdoerffer, NCI; Nirali N. 2 National Cancer Institute shalini. To achieve base-resolution mapping of ac4C, we employed sodium borohydride (NaBH 4) reduction of ac4C. Zengeya Shalini Oberdoerffer. This An emerging concept in co‐transcriptional splicing is the potential for extensive cross talk between the splicing machinery and the chromatin structure of the transcribed DNA template (reviewed I am a Staff Scientist at LRBGE, CCR, NCI. 09:30 am - 10:00 am EST Do EcDNAs Have Special Properties in the Nucleus That Drive Oncogene Expression in This protocol utilized the Center for Cancer Research (CCR) Sequencing Facility for the National Cancer Institute (NCI, Frederick, MD) for Illumina sequencing services. Building 41, Room B626. Research Topics. PMID: 22771943.
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